Pharmaceutical Tablet Press Machine
OM Exim -Pharmaceutical Tablet Press in Ahmedabad
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The f’ll’st equipment reported in the pharmaceutical literature to provide continuous-batch wet granulation was fluid-bed drying equipment which was modified by the addition of spray nozzles or fluid injectors to provide additional liquid-binding and adhesive agents to powdered materials which were initially placed in the equipment. Scientists working in European pharmaceutical companies so the first to report on this approach
A number of pharmaceutical companies, both in Europe and in The United States, are utilizing fluid-bed processing as a rapid continuous batch approach to wet granulation.
However, there are a number of difficulties that exist for the process which may account for the fact that fluid-bed granulation processing has not been more widely accepted. Fluid-bed systems as currently available may provide adequate mixing of powder components.
Pharmaceutical Tablet Machine in Gujarat
OM Exim have the quality of the Pharmaceutical Tablet Press Machine in Ahmedabad Gujarat India. Where potent drugs are employed in a fine state of particle size reduction, there will be a tendency of these materials to be separated from the powdered bed and collected on the filter Pharmaceutical Tablet Press Machine.
Thus, even if a separate powder-mixing operation is undertaken to produce adequate uniformity of drug distribution within the mix, thus demixing action must be considered in any attempt to process potent drugs in a fluid-bed spray granulator or when there is a considerable disparity in the particle size or density of the materials being processed. Pharmaceutical Tablet Press in Ahmedabad,
use of other more conventional mixing equipment. the forces of agglomeration which cause the particles to be brought together producing the agglomerates are relatively low in the fluid-bed spray granulator.
Accordingly, not all materials may lend themselves to agglomeration in this continuous batch-processing Pharmaceutical Tablet Press in Ahmedabad. Low-density and hydrophobic materials can be particularly troublesome. Another limitation of this type of equipment may be related to particles containing granulating agent on their surfaces which adhere to the filters of the equipment.
A number of fatal accidents have occurred worldwide with the use of fluid-bed dryers, as have a number of less serious explosions in which only the installation was damaged or destroyed. Dust explosions can also occur in fluid-bed dryer with dry materials. However, when working with solvents. especially those with Pharmaceutical Tablet Press in Ahmedabad. it might be wise to Ill’st check with the supplier of the equipment to review whether or not the operation is safe or advisable.
Other manufacturers of fluidized-bed drying equipment, such as Glatt Air Techniques, have developed specialized equipment to provide continuous batch processing fluid-bed granulator capabilities Pharmaceutical Tablet Machine in Gujarat.
The number of scientific papers that have appeared in this field in recent years attests to the interest of the pharmaceutical industry in this continuous-batch processing approach. Pharmaceutical Tablet Press Machine manufacturers, investigators have studied the mixing of pharmaceutical raw materials in heterogeneous fluidized Pharmaceutical Tablet Machine in Gujarat.
A large number of manufacturers of both double-cone and twin-shell blenders have produced equipment modifications that provide the potential for sequencing the operations of powder mixing, wet massing, agglomeration, and Pharmaceutical Tablet Machine in Gujarat.
The specialized equipment typically includes a liquid feed through the trunion of the machine leading to a spray dispenser located above the axis of rotation of the unit so Pharmaceutical Tablet Press Machine manufacturers, a vacuum inlet through the same or the opposing trunion leading to a vacuum intake port covered by nylon or another appropriate fine-filter sleeve,
also located above the axis of rotation and out of the direct path of powder motion, and agitating elements capable of rotation within the powder mass contained in the blender. In some cases, the blender will also be of a double-wall construction to provide circulation of a heating medium Pharmaceutical Press Machine in India; in other eases the systems are designed to operate at room temperature and use vacuum as the Pharmaceutical Press Machine in india.
A number of pharmaceutical manufacturers have used this type of equipment for production manufacture of granulations Pharmaceutical Press Machine in India. The equipment is commercially available and has been for a number of years. As in any vacuum-drying operation. equipment cost is high and drying costs are relatively high. Drying times will be considerably longer than so the case with the fluid bed granulator processor.
The double-cone or twin shell processor would, so considerably easier to clean. The attractiveness today of the double-cone or twin-shell mixer. granulator and dryer as a continuous batch processor of wet granulation products hinge on the use of nonaqueous granulating Pharmaceutical Press Machine in India.
Standard auxiliary equipment is available to condense solvent vapors and provide substantially complete solvent recovery. This is important for two standpoints: solvent vapors are not discharged to the atmosphere. an environmental consideration, and efficient solvent recovery is achievable.
As such. it is a modification of an alternative to a double-cone blender which rotates about its axis to produce the tumbling of the particles within the cone. In the vertical screw mixer. the screw does the work to lift the powder in the cone and the cone does not rotate Pharmaceutical Tablet Press Machine manufacturers. In some vertical screw mixers. the screw assembly is fixed, Whereas in others the screw assembly orbits around the vessel walls to ensure more uniform mixing throughout the entire bed.
There are several advantages of the Nauta processor equipment over the two types of continuous-batch processor granulators described in earlier parts of this section. Unlike the fluid-bed dryer Pharmaceutical Tablet Press Machine manufacturers, the Nauta mixer/processor is inherently a powder mixer
and is capable of producing very the uniform powder mixtures which do not demix. Unlike the double-cone and twin blenders described in the preceding section,
The Nauta processor is not forced rely on vacuum for drying but can use hot air. As noted previously, vacuum equipment is inherently expensive to manufacture, operate, and maintain, and it is also difficult to maintain close control of product temperatures Pharmaceutical Tablet Press Machine manufacturers,
Pharmaceutical Tablet Press in Ahmedabad, Pharmaceutical Tablet Machine in Gujarat, Pharmaceutical Press Machine in India, Pharmaceutical Tablet Press Machine manufacturers.
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